M. J. Rivas López, J. López Fidalgo
Accelerated Failure Time (AFT) models are widely used in the field of manufacturing, for example in studies on time up to the break of materials used in in structures of engineering. Nowadays there is an increasing interest in using AFT models for clinical trials as some literature reflects. These models focus on the direct effect of the explanatory variables on the survival function instead of the hazard function in the Proportional Hazards models. This property allows for an easier interpretation measuring directly the effect of the corresponding covariate on the survival time. Fisher Information Matrix for AFT models and approximate designs are computed, for Type I and random censoring. D-optimal designs for the particular case of Log-Logistic AFT model will be computed for a case study.
Palabras clave: AFT models, Optimal design, Survival analysis
Programado
X04 Pausa Café. Sesión Posters. Reunión TEST - Edificio 1
7 de septiembre de 2016 11:40
Edificio 1