M. Higueras Hernáez, E. Ainsbury, P. Puig
Biological retrospective dosimetry analyses the induced damage at a cellular level by ionising radiation in overexposed individuals. This damage is represented by chromosomal aberrations, e.g. dicentrics, which are counted from peripheral blood lymphocytes. The yield of chromosomal aberrations is typically assumed to be Poisson distributed, whose intensity is a quadratic function of the absorbed dose.
The estimation of the dose absorbed by an individual requires dose-effect calibration curves. They are produced by irradiating peripheral blood lymphocytes to a range of doses, simulating homogeneous whole body irradiation.
Gradient exposures are heterogeneous irradiations where different doses incise in the individual's body at different parts. In this scenario, the process of the yield of chromosomal aberrations per cell can be represented by a Poisson finite mixture process. New Bayesian-like models are proposed for the absorbed doses and fractions irradiated estimation.
Palabras clave: Poisson mixture, zero-inflation, Bayesian inverse problem.
Programado
L06.3 Sesión de la Sociedad Española de Biometría
5 de septiembre de 2016 12:55
Aula 21.08
